Cefpodoxime proxetil is indicated for the trea tment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the conditions listed below :
Acute otitis media caused by Streptococcus pneumoniae (excluding penicillin-resistant strains), Streptococcus pyogenes, Haemophil us influenzae (including beta-lactamase-producing strains), or Moraxella (Branhamella) catarrhalis (including beta-lactamase-producing strains) .
Pharyngitis and/or tonsillitis caused by Streptococcus pyogenes .
Community-acquired pneumonia caused by S. pneumoniae or H. influenzae (including beta-lactamase-producing strains) .
Acute bacterial exacerbation of chronic bronchitis caused by S. pneumoniae, H. influenzae (non-beta-lactamase-producing strains only), or M. ca tarrhalis . Data are insufficient at this time to establish efficacy in patients with acute bacterial exacerbations of chronic bronchitis caused by beta-lactamase-producing strains of H. influenzae .
Acute, unco mplicated urethral and cervical gonorrhea caused by Ne isseria gonorrhoeae (including penicillinase-producing strains) .
Acute, uncomplicated anorectal infections in women due to Neisseria gonorrhoeae (including penicillinase-producing strains) .
Uncomplicated skin and skin structure infections caused by Staphylococcus aureus (including penicillinase-producing strains) or Streptococ cus pyogenes . Abscesses should be surgically drained as clinically indicated .
Acute maxillary sinusitis caused by Haemophilus influenzae (including beta-lactamase-producing strains), Streptococcus pneumoniae, and M oraxella catarrhalis .
Uncomplicated urinary tract infections (cystitis) caused by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, or Staphylococcus saprophyticus .
Cefpodoxime proxetil is an orally administered, extended spectrum, semi-synthetic antibiotic of the cephalosporin class . The chemical name is (RS)-1(isopropoxycarbonyloxy) ethyl(+)-(6R,7R)-7-[2-(2-amino-4-thiazolyl)-2-{(Z)methoxyimino}acetamido]-3-methoxymethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate . Its empirical formula is C21H27N5O9S2 . The molecular weight of cefpodoxime proxetil is 557.6 .
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