Alfa-D is an active form of vitamin D3. It is an agent for the improvement of calcium metabolism and the promotion of bone formation. Alfa-D is directly converted into its active form 1a, 25 (OH)2 D3 in liver by 25-hydroxylase and acts on intestine, bone, kidney and parathyroid gland. As compared to vitamin D, a main advantage of Alfa-D alfacalcidol is more rapid onset and reversal of action which allows a more accurate dose titration and decreases the risk of prolonged hypercalcaemia.
Indications: Diseases caused by disturbances in the calcium metabolism due to abnormal vitamin D metabolism. Bone diseases due to chronic renal failure, osteoporosis, vitamin D dependent / resistant rickets and osteomalacia, post operative or idiopathic hypoparathyroidism, pseudohypoparathyroidism, and as an adjunct to the management of tertiary hyperparathyroidism.
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